Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients
Step 1: Look for available data and determine adequacy
Step 2: Read-across data or in vitro/ in silico methods
Step 3: Exposure Threshold
Step 4: Generate Required Data (on material, metabolic pathway, or analogue to build a read-across structure)
Step 1: Look for available data and determine adequacy
Step 2: Read-across data or in vitro/ in silico methods
Step 3: Exposure Threshold
Step 4: Generate Required Data (on material, metabolic pathway, or analogue to build a read-across structure)