News in computational toxicology
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NAMs and acute systemic toxicity
The paper discusses the global regulatory requirements for assessing the systemic toxicity of chemicals through various exposure routes (oral, dermal, and inhalation) for human health risk assessment. It focuses on the efforts of the International Cooperation on Alternative Test Methods (ICATM) to identify opportunities for using non-animal replacements for these tests.
Innovative solutions for enhancing chemical safety assessment
Both papers present a way to address one of the major challenge of chemical safety assessment that is the sheer scale of the assessment exercise: a new classification scheme designed to lead to the same levels of protection, without necessarily aiming to predict adverse effects in animal studies. The new classification scheme will rank chemicals into three levels of concern (high, medium and low) based on toxicodynamic (TD) and toxicokinetic (TK) considerations.
A KNIME Workflow to Assist the Analogue Identification for Read-Across, Applied to Aromatase Activity
EPA - Availability of New Approach Methodologies (NAMs) in the Endocrine Disruptor Screening Program (EDSP)
Symposium Explores Application of NAMs to Tobacco Products
A new publication reports on a 2021 symposium that explored the use of new approach methodologies for regulatory decision making for tobacco products.